GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity

GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity

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Main Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity? In order to answer this question, we need to understand how receptors and their signalling partners are synthesized, folded and quality-controlled in order to generate functional proteins. Then, we need to understand how each partner of the signalling complex is selected to join a complex, and what makes this assembly possible. GPCRs are known to be able to function as oligomers, what drives the assembly into oligomers and what will be the effects of such organization on specificity and efficacy of signal transduction. Once the receptor complexes are assembled, they need to reach different locations in the cell; what drives and controls the trafficking of GPCR signalling complexes. Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCRs signalling complexes; how can we manipulate the system to make it function normally again? Pharmacological chaperones may just be part of the answer to this question.The red lines indicate the position of the C14a€“C200 and C114a€“C196 disulfide bridges; the light purple dashed line pair ... 2006b), (c) Schematic representation of the primary and secondary structure of the hGnRHR based on the modelanbsp;...

Title:GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity
Author: Denis J. Dupré, Terence E. Hébert, Ralf Jockers
Publisher:Springer Science & Business Media - 2012-11-19

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